Organocatalysis (Ernst Schering Foundation Symposium Proceedings)

Ernst Schering Foundation Symposium Proceedings 2007-2 Organocatalysis Ernst Schering Foundation Symposium Proceedings 2007-2 Organocatalysis M.T. Reetz, B. List, S. Jaroch, H. Weinmann Editors With 200 Figures 123 Series Editors: G. Stock and M. Lessl Library of Congress Control Number: 2007943075 ISSN 0947-6075 ISBN 978-3-540-73494-9 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublication does not emply, even in the absence of a specific statemant, that such names are exempt from therelevant protectivelawsand regulationsandthereforfree forgeneraluse. Product liability: The publisher cannot guarantee the accuracy any information about dosage and application contained in this book. In every induvidual case the user must check such information by consulting the relevant literature. Cover design: design & production, Heidelberg Typesetting and production: le-tex publishing services oHG, Leipzig 21/3180/YL – 5 4 3 2 1 0 Printed on acid-free paper Preface Chemical synthesis is one of the key technologies that form the basis of modern drug discovery and development. For the rapid preparation of new test compounds and the development of candidates with often highly complex chemical structures, it is essential to use state-of-the-art chemical synthesis technologies. Due to the increasing number of chiral drugs in the pipeline, asymmetric synthesis and efficient chiral separation technologies are steadily gaining in importance. Recently a third class of catalysts, besides the established enzymes and metal complexes, has been added to the tool kit of catalytic asymmetric syn-thesis: organocatalysts, small organic molecules in which a metal is not part of the active principle. Despiteconsiderable effortstoexploreandextendthescopeofasym-metric organocatalytic reactions in recent years, their use in medicinal and process chemistry is still rather low. This is even more surpris-ing as the field was pioneered by the medicinal chemistry laboratories of Schering AG and Hoffmann La Roche in the late 1960s and early 1970s by using proline as asymmetric catalyst in a Robinson annulation to obtain steroid CD ring fragments, a process now referred to as the Hajos–Parrish–Eder–Sauer–Wiechert reaction. Inanefforttoincreasetheawarenesswithinthecommunityofmedic-inal and process chemists, and to learn more about recent progress in this rapidly evolving field, the Ernst Schering Foundation enabled us to ... - tailieumienphi.vn