In addition to local periodontal tissue involvement, chronic infection of the periodontium together with continuous up-regulation of pro-inflammatory responses and immune mediators may contribute to systemic sequel including diabetes, preterm delivery of lowweight birth babies, lung inflammation, arthritis and cardiovascular diseases (CVD). In fact, numerous case-control and cohort studies have demonstrated that periodontitis patients exert increased risk for CVD, acute myocardial infarction (AM