The biologic phenotype underlying chronic periodontitis, including the biofilm and the host response, tend to vary among individuals despite a similar clinical diagnostic category (Offenbacher et al. 2007). Consequently, disease screening should ideally be based on clinical determinations and the biologic phenotype (Page and Kornman 1997). Other associated factors include environmental exposures, as well as differences in genetic and possibly epigenetic composition (Page and Kornman 1997).