MEDICINAL CHEMISTRY AND DRUG DESIGN

MEDICINAL CHEMISTRY AND DRUG DESIGN Edited by Deniz Ekinci Medicinal Chemistry and Drug Design Edited by Deniz Ekinci Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Molly Kaliman Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published April, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Medicinal Chemistry and Drug Design, Edited by Deniz Ekinci p. cm. ISBN 978-953-51-0513-8 Contents Preface IX Chapter 1 Chapter 2 Kojic Acid Derivatives 1 Mutlu D. Aytemir and G. Karakaya Analysis of Protein Interaction Networks to Prioritize Drug Targets of Neglected-Diseases Pathogens 27 Aldo Segura-Cabrera, Carlos A. García-Pérez, Mario A. Rodríguez-Pérez, Xianwu Guo, Gildardo Rivera and Virgilio Bocanegra-García Chapter 3 Chapter 4 Chapter 5 Recent Applications of Quantitative Structure-Activity Relationships in Drug Design 55 Omar Deeb Atherosclerosis and Antihyperlipidemic Agents 83 Laila Mahmoud Mohamed Gad Inhibitors of Serine Proteinase – Application in Agriculture and Medicine 103 Rinat Islamov, Tatyana Kustova and Alexander Ilin Chapter 6 Chapter 7 Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents 119 Ahmed Kamal, M. Kashi Reddy, Ajay Kumar Srivastava and Y. V. V. Srikanth Regulation of EC-SOD in Hypoxic Adipocytes 143 Tetsuro Kamiya, Hirokazu Hara, Naoki Inagaki and Tetsuo Adachi Chapter 8 Development of an Ultrasensitive CRP Latex Agglutination Reagent by Using Amino Acid Spacers 159 Tomoe Komoriya, Kazuaki Yoshimune, Masahiro Ogawa, Mitsuhiko Moriyama and Hideki Kohno ... - tailieumienphi.vn