In the last decade, scientists began to use signaling molecules such as growth factors in their quest to restore destroyed tooth support (Anusaksathien & Giannobile, 2002) and this reason request a very good knowledge of the biological actions of growth factors, both summative and redundant, in the specific “milieu” of periodontal diseases. This paper highlights a brief review of the literature on growth factors involvement in periodontal disease and our contribution in this field, in order to s