Acne Symposium at the World Congress of Dermatology Pari

Acne Symposium at the World Congress of Dermatology Paris, July, 2002 Editors Ch.C. Zouboulis, Berlin M.I. Herane, Santiago de Chile D.Thiboutot, Hershey, Pa. 24 figures, 16 in color, and 18 tables, 2003 BaselN FreiburgN ParisN LondonN New YorkN BangaloreN BangkokN SingaporeN Tokyo N Sydney Editors: Christos C. Zouboulis Department of Dermatology University Medical Center Benjamin Franklin The Free University of Berlin Fabeckstrasse 60–62 14195 Berlin (Germany) Tel. 49-30-84456910 Fax 49-30-84456908 E-mail zouboulis@medizin.fu-berlin.de Maria Isabel Herane Department of Dermatology West Unit University of Chile Hospital San Juan de Dios Guardia Vieja 255 of. 901 Providencia, Santiago (Chile) Tel. 56-2-3310449 Fax 56-2-3310450 E-mail giderm@yahoo.es Diane Thiboutot Department of Dermatology Milton Hershey Medical Center Pennsylvania State University P.O. Box 850 Hershey, PA 17033 (USA) Tel. 1-717-531-8307 Fax 1-171-531-4821 E-mail dthiboutot@psu.edu S. Karger Medical and Scientific Publishers Basel N Freiburg N Paris N London New York N Bangalore N Bangkok Singapore N Tokyo N Sydney Drug Dosage The authors and the publisher have exerted every effort to en-sure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of informa-tion relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precau-tions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see ‘General Information’). © Copyright 2003 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) Printed in Switzerland on acid-free paper by Reinhardt Druck, Basel ISBN 3–8055–7548–3 Fax + 41 61 306 12 34 E-Mail karger@karger.ch www.karger.com Vol. 206, No. 1, 2003 Contents 4 Editorial: Current and Future Aspects on Acne Zouboulis, Ch.C. (Berlin); Herane, M.I. (Santiago); Thiboutot, D. (Hershey, Pa.) 5 Foreword and Critical Remarks Strauss, J.S. (Iowa City, Iowa) 7 Epidemiology of Acne Dreno, B. (Nantes); Poli, F. (Créteil) 11 Comedogenesis: Some Aetiological, Clinical and Therapeutic Strategies Cunliffe, W.J.; Holland, D.B.; Clark, S.M.; Stables, G.I. (Leeds) 17 New Aspects in Acne Inflammation Toyoda, M.; Morohashi, M. (Toyama) 24 Acne in Infancy and Acne Genetics Herane, M.I. (Santiago); Ando, I. (Kawasaki) 29 Topical Treatment in Acne. Current Status and Future Aspects Gollnick, H.P.M.; Krautheim, A. (Magdeburg) 37 Update and Future of Systemic Acne Treatment Zouboulis, Ch.C. (Berlin); Piquero-Martin, J. (Caracas) 54 Propionibacterium acnes Resistance: A Worldwide Problem Eady, E.A. (Leeds); Gloor, M. (Karlsruhe); Leyden, J.J. (Philadelphia, Pa.) 57 Update and Future of Hormonal Therapy in Acne Thiboutot, D. (Hershey, Pa.); Chen, W. (Tainan) 68 Less Common Methods to Treat Acne Kaminsky, A. (Buenos Aires) 74 Author Index 74 Subject Index © 2003 S. Karger AG, Basel Fax + 41 61 306 12 34 E-Mail karger@karger.ch www.karger.com Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/drm_issues Editorial: Current and Future Aspects on Acne Dear colleagues and friends, It is a great pleasure to present the Proceedings of the Symposium on Acne held at the 20th World Congress of Dermatology, July 1–5, 2002 in Paris. The topics dis-cussed have been selected to address current and future aspects of research, clinical entities and treatment of the most common human disease. The manuscripts represent a cooperative effort of 20 experts on acne from literally all around the globe. They are state-of-the-art reports including data on the increas-ing evidence of acne occurrence in a considerable amount of adults, especially females, the cycling of normal folli-cles and of comedones that may explain the natural reso-lution of comedones and, in the longer term, of the disease itself, evidence that cutaneous neurogenic factors contrib-ute to the onset and/or exacerbation of acne inflamma-tion, first data that chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and the MUC1 gene may be involved in the patho-genesis of acne, new topical therapeutic regimens, sys-temic drugs, and concepts for their use, in association to the need of developing strategies to minimize use of anti-biotics in acne therapy, the endocrine aspects of acne and their selective treatment, and effective acne medication alternatives for countries which cannot afford modern treatments. In addition, Prof. John S. Strauss, Iowa City, wrote a comprehensive summary of the most important data and highlighted concepts for pathogenesis-tailored acne treatment. This publication addresses equally clinicians and scientists interested in acne and determines the revolu-tion which occurred recently in acne research and will probably continue in the future. We express our sincere thanks to Prof. Jean-Hilaire Saurat, Geneva, Switzerland, Editor-in-Chief of Derma-tology and Mr. Thomas Karger, Ms. Susanna Ludwig, and Ms. Elisabeth Anyawike from S. Karger AG for their help in the realization of this project as a peer-reviewed publi-cation under most favorable conditions. Hoping that you will find this Dermatology thematic issue interesting, informative, and stimulating, we wish you a pleasant reading. Prof. Dr. Christos C. Zouboulis, Berlin Prof. Dr. Maria Isabel Herane, Santiago de Chile Prof. Dr. Diane Thiboutot, Hershey, Pa., USA Prof. Dr. Christos C. Zouboulis, Berlin Prof. Dr. Maria Isabel Herane, Santiago de Chile Prof. Dr. Diane Thiboutot, Hershey, Pa., USA ABC Fax +41 61 306 12 34 E-Mail karger@karger.ch www.karger.com © 2003 S. Karger AG, Basel Accessible online at: www.karger.com/drm ... - tailieumienphi.vn